Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 12000.166 | 0.9682 | 0.9154 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 12000.166 | 0.9735 | 0.9292 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 12000.166 | 1.0064 | 1.0171 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 12000.166 | 1.0384 | 1.1036 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 12000.166 | 0.5776 | -0.0409 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000128 | uM | 12084.161 | 0.9740 | 0.9640 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00064 | uM | 12084.161 | 0.9533 | 0.9350 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0032 | uM | 12084.161 | 0.9979 | 0.9971 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.016 | uM | 12084.161 | 1.0857 | 1.1168 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.08 | uM | 12084.161 | 0.9507 | 0.9314 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.4 | uM | 12084.161 | 0.9922 | 0.9892 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 2 | uM | 12084.161 | 0.9257 | 0.8963 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 10 | uM | 12084.161 | 0.8146 | 0.7360 | 1.4492 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 50 | uM | 12084.161 | 0.1195 | -0.5384 | 1.4492 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12001.166 | 0.9639 | 0.8720 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12001.166 | 0.9318 | 0.7617 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12001.166 | 0.9754 | 0.9123 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12001.166 | 0.8833 | 0.6002 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12001.166 | 0.8955 | 0.6402 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 12001.166 | 0.9239 | 0.7350 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 12001.166 | 0.8667 | 0.5467 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 12001.166 | 0.9190 | 0.7184 | 0.5565 | |
| HCC1419 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 12001.166 | 0.6746 | -0.0141 | 0.5565 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10693.149 | 1.0306 | 1.0704 | 0.8714 | |
| HCC1428 | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10693.149 | 1.0210 | 1.0482 | 0.8714 |