Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 6.67 | uM | 12566.166 | 0.5464 | 0.2092 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 33.3 | uM | 12566.166 | 0.1729 | -0.5360 | 1.2010 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12224.161 | 1.0093 | 1.0262 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12224.161 | 0.9280 | 0.8013 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12224.161 | 1.0364 | 1.1026 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12224.161 | 1.0201 | 1.0565 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12224.161 | 1.0452 | 1.1278 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12224.161 | 1.0438 | 1.1238 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12224.161 | 0.9730 | 0.9247 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12224.161 | 0.7639 | 0.3714 | 0.7139 | |
| 600MPE | HR+ | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12224.161 | 0.2500 | -0.7132 | 0.7139 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10880.149 | 1.0057 | 1.0070 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000427 | uM | 10880.149 | 0.9988 | 0.9985 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00213 | uM | 10880.149 | 0.9856 | 0.9823 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0107 | uM | 10880.149 | 1.0247 | 1.0302 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0533 | uM | 10880.149 | 0.9425 | 0.9286 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.267 | uM | 10880.149 | 1.0170 | 1.0208 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 1.33 | uM | 10880.149 | 0.9203 | 0.9006 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 6.67 | uM | 10880.149 | 0.9391 | 0.9243 | 1.6289 | |
| AU565 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 33.3 | uM | 10880.149 | 0.6760 | 0.5726 | 1.6289 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10581.137 | 1.0092 | 1.0154 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10581.137 | 0.9022 | 0.8353 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10581.137 | 0.9617 | 0.9358 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10581.137 | 0.9291 | 0.8809 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10581.137 | 0.9823 | 0.9703 | 1.1975 |