Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.000341 | uM | 11939.144 | 0.9869 | 0.9841 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00171 | uM | 11939.144 | 0.9389 | 0.9248 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.00853 | uM | 11939.144 | 1.0107 | 1.0130 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.0427 | uM | 11939.144 | 1.0196 | 1.0237 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 0.213 | uM | 11939.144 | 0.9784 | 0.9736 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 1.07 | uM | 11939.144 | 1.0119 | 1.0145 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 5.33 | uM | 11939.144 | 0.4472 | 0.2261 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 26.7 | uM | 11939.144 | 0.6663 | 0.5625 | 1.6446 | |
| ZR75B | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 133 | uM | 11939.144 | 0.6084 | 0.4784 | 1.6446 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12509.166 | 1.0729 | 1.1126 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12509.166 | 1.0111 | 1.0173 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12509.166 | 1.0057 | 1.0089 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12509.166 | 1.0270 | 1.0419 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12509.166 | 1.0652 | 1.1007 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 0.267 | uM | 12509.166 | 0.8287 | 0.7278 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 1.33 | uM | 12509.166 | 0.9817 | 0.9715 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 6.67 | uM | 12509.166 | 0.7958 | 0.6743 | 1.2847 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 33.3 | uM | 12509.166 | 0.0834 | -0.7107 | 1.2847 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12566.166 | 1.0339 | 1.0563 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.000427 | uM | 12566.166 | 0.9985 | 0.9975 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.00213 | uM | 12566.166 | 0.9989 | 0.9981 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.0107 | uM | 12566.166 | 1.0899 | 1.1486 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.0533 | uM | 12566.166 | 1.0884 | 1.1461 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 0.267 | uM | 12566.166 | 1.0636 | 1.1053 | 1.2010 | |
| 184B5 | NM | Basal | L-779450 | BRAF | MAPK | 1.33 | uM | 12566.166 | 0.8641 | 0.7711 | 1.2010 |