Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12254.154 | 0.9738 | 0.9677 | 1.6307 | |
| MCF 10F | NM | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12254.154 | 0.7956 | 0.7383 | 1.6307 | |
| MCF 10F | NM | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12254.154 | 0.1428 | -0.3937 | 1.6307 | |
| MCF 10F | NM | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12254.154 | 0.0287 | -0.7731 | 1.6307 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10817.154 | 1.0178 | 1.0243 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10817.154 | 0.9710 | 0.9600 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10817.154 | 1.0299 | 1.0409 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 10817.154 | 1.0357 | 1.0489 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 10817.154 | 1.0447 | 1.0610 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 10817.154 | 0.8420 | 0.7771 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 10817.154 | 0.3965 | 0.0590 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 10817.154 | 0.2093 | -0.3173 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 10817.154 | 0.0935 | -0.6076 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 12365.167 | 1.0028 | 1.0028 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 12365.167 | 1.0248 | 1.0243 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 12365.167 | 1.0163 | 1.0161 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0107 | uM | 12365.167 | 1.0597 | 1.0581 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0533 | uM | 12365.167 | 0.8724 | 0.8698 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.267 | uM | 12365.167 | 0.6755 | 0.6481 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 1.33 | uM | 12365.167 | 0.3252 | 0.1492 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 6.67 | uM | 12365.167 | 0.1284 | -0.2735 | 2.0273 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 33.3 | uM | 12365.167 | 0.0177 | -0.7263 | 2.0273 | |
| MCF7 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.0000853 | uM | 10997.154 | 0.9946 | 0.9901 | 1.0978 | |
| MCF7 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.000427 | uM | 10997.154 | 1.0365 | 1.0665 | 1.0978 | |
| MCF7 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 0.00213 | uM | 10997.154 | 0.9938 | 0.9887 | 1.0978 |