Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.00252 | uM | 7553.095 | 0.9498 | 0.9122 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0126 | uM | 7553.095 | 0.7851 | 0.6197 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0631 | uM | 7553.095 | 0.6068 | 0.2940 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.316 | uM | 7553.095 | 0.5369 | 0.1630 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 1.58 | uM | 7553.095 | 0.6012 | 0.2835 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7.89 | uM | 7553.095 | 0.6998 | 0.4652 | 1.1473 | |
| ZR-75-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 39.4 | uM | 7553.095 | 0.0081 | -0.9700 | 1.1473 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.000101 | uM | 7555.095 | 0.9720 | 0.9691 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.000505 | uM | 7555.095 | 0.8846 | 0.8699 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.00252 | uM | 7555.095 | 0.7160 | 0.6651 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0126 | uM | 7555.095 | 0.6205 | 0.5393 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.0631 | uM | 7555.095 | 0.6174 | 0.5351 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 0.316 | uM | 7555.095 | 0.5733 | 0.4739 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 1.58 | uM | 7555.095 | 0.5451 | 0.4337 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7.89 | uM | 7555.095 | 0.6849 | 0.6250 | 1.8227 | |
| ZR75B | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 39.4 | uM | 7555.095 | 0.0065 | -0.8742 | 1.8227 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 0.000512 | uM | 12509.168 | 1.0038 | 1.0056 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 0.00256 | uM | 12509.168 | 1.0577 | 1.0848 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 0.0128 | uM | 12509.168 | 1.0103 | 1.0152 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 0.064 | uM | 12509.168 | 0.9555 | 0.9337 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 0.32 | uM | 12509.168 | 1.0045 | 1.0066 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 1.6 | uM | 12509.168 | 0.7669 | 0.6434 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 8 | uM | 12509.168 | 0.7439 | 0.6068 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 40 | uM | 12509.168 | 0.9061 | 0.8592 | 1.3516 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 200 | uM | 12509.168 | 0.6091 | 0.3859 | 1.3516 |