Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7512.067 | 0.9959 | 0.9907 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7512.067 | 0.8927 | 0.7564 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7512.067 | 0.6097 | 0.1352 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7512.067 | 0.6326 | 0.1841 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7512.067 | 0.5927 | 0.0989 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7512.067 | 0.1161 | -0.8300 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7512.067 | 0.0056 | -0.9947 | 0.8735 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7517.067 | 1.0632 | 1.0909 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7517.067 | 1.0247 | 1.0358 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7517.067 | 1.0211 | 1.0306 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7517.067 | 1.0288 | 1.0417 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7517.067 | 0.3111 | -0.1430 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7517.067 | 0.2897 | -0.1863 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7517.067 | 0.3156 | -0.1341 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7517.067 | 0.3006 | -0.1641 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7517.067 | 0.0037 | -0.9658 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7518.067 | 0.9374 | 0.8383 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7518.067 | 1.0322 | 1.0844 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7518.067 | 1.0323 | 1.0847 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7518.067 | 0.9461 | 0.8605 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7518.067 | 0.3180 | -0.5512 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7518.067 | 0.3028 | -0.5791 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7518.067 | 0.3447 | -0.5014 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7518.067 | 0.2282 | -0.7089 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7518.067 | 0.0044 | -0.9983 | 0.7666 |