Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7523.067 | 0.9635 | 0.9133 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7523.067 | 0.9241 | 0.8202 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7523.067 | 0.9818 | 0.9566 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7523.067 | 0.9822 | 0.9576 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7523.067 | 0.4542 | -0.2201 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.267 | uM | 7523.067 | 0.3919 | -0.3461 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 1.33 | uM | 7523.067 | 0.4029 | -0.3241 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 6.67 | uM | 7523.067 | 0.3229 | -0.4810 | 0.8380 | |
| MX1 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 33.3 | uM | 7523.067 | 0.0077 | -0.9940 | 0.8380 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7526.067 | 1.0452 | 1.0492 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7526.067 | 1.0201 | 1.0220 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7526.067 | 0.9569 | 0.9522 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7526.067 | 0.9141 | 0.9036 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7526.067 | 0.1821 | -0.2159 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7526.067 | 0.1017 | -0.4307 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7526.067 | 0.1063 | -0.4167 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7526.067 | 0.1434 | -0.3124 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7526.067 | 0.0084 | -0.8550 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7527.067 | 0.9945 | 0.9942 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7527.067 | 0.9866 | 0.9860 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7527.067 | 0.9562 | 0.9539 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7527.067 | 1.0037 | 1.0039 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7527.067 | 0.2450 | -0.0395 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7527.067 | 0.1452 | -0.2689 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7527.067 | 0.1807 | -0.1805 | 1.9179 |