Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7527.067 | 0.1407 | -0.2806 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7527.067 | 0.0062 | -0.8582 | 1.9179 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7528.067 | 1.0279 | 1.0595 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7528.067 | 1.0298 | 1.0637 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7528.067 | 1.0164 | 1.0349 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7528.067 | 1.0261 | 1.0556 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7528.067 | 0.2702 | -0.5040 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7528.067 | 0.2150 | -0.6111 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7528.067 | 0.2140 | -0.6130 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7528.067 | 0.1991 | -0.6416 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7528.067 | 0.0014 | -0.9982 | 0.9386 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 9044.067 | 0.8984 | 0.4324 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 9044.067 | 0.7795 | -0.0795 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 9044.067 | 0.9933 | 0.9584 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 9044.067 | 0.9603 | 0.7629 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 9044.067 | 0.1669 | -0.9924 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 9044.067 | 0.1976 | -0.9872 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 9044.067 | 0.2424 | -0.9758 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 9044.067 | 0.1571 | -0.9937 | 0.3210 | |
| SUM1315MO2 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 9044.067 | 0.0055 | -1.0000 | 0.3210 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7530.067 | 1.0752 | 1.0711 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7530.067 | 1.0053 | 1.0051 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7530.067 | 0.9845 | 0.9850 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7530.067 | 0.9603 | 0.9614 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7530.067 | 0.3397 | 0.1885 | 2.0748 |