Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7508.067 | 0.2572 | -0.6681 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7508.067 | 0.2213 | -0.7280 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7508.067 | 0.2257 | -0.7209 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7508.067 | 0.2688 | -0.6482 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7508.067 | 0.0069 | -0.9972 | 0.7560 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7510.067 | 1.0332 | 1.0799 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7510.067 | 1.0257 | 1.0618 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7510.067 | 1.0617 | 1.1488 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7510.067 | 0.9255 | 0.8229 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7510.067 | 0.6821 | 0.2647 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7510.067 | 0.5864 | 0.0553 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7510.067 | 0.6578 | 0.2110 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7510.067 | 0.3562 | -0.4193 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7510.067 | 0.0005 | -0.9998 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7511.067 | 1.0658 | 1.1166 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7511.067 | 1.0649 | 1.1151 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7511.067 | 1.0620 | 1.1100 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7511.067 | 0.8394 | 0.7116 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7511.067 | 0.6539 | 0.3709 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7511.067 | 0.6016 | 0.2729 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7511.067 | 0.6159 | 0.2998 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7511.067 | 0.1187 | -0.6994 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7511.067 | 0.0012 | -0.9948 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7512.067 | 1.0047 | 1.0108 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7512.067 | 1.0612 | 1.1408 | 0.8735 |