Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7492.067 | 0.8589 | 0.7975 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7492.067 | 0.5042 | 0.2366 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7492.067 | 0.4779 | 0.1910 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7492.067 | 0.5096 | 0.2459 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7492.067 | 0.0488 | -0.7601 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7492.067 | 0.0064 | -0.9422 | 1.4243 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7493.067 | 0.9960 | 0.9942 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7493.067 | 0.9577 | 0.9378 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7493.067 | 0.9032 | 0.8567 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7493.067 | 0.9313 | 0.8987 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7493.067 | 0.4709 | 0.1534 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7493.067 | 0.4009 | 0.0255 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7493.067 | 0.4905 | 0.1884 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7493.067 | 0.2047 | -0.3725 | 1.3684 | |
| MCF7 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7493.067 | 0.0030 | -0.9712 | 1.3684 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7494.067 | 0.9470 | 0.8780 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7494.067 | 0.9287 | 0.8361 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7494.067 | 1.0041 | 1.0096 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7494.067 | 1.0029 | 1.0068 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7494.067 | 0.6944 | 0.3120 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7494.067 | 0.3443 | -0.4170 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7494.067 | 0.3170 | -0.4701 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7494.067 | 0.3412 | -0.4231 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7494.067 | 0.0055 | -0.9951 | 0.8649 | |
| MDA-MB-157 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7495.067 | 1.0545 | 1.0964 | 1.1275 |