Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7448.067 | 0.5001 | 0.5678 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7448.067 | 0.5114 | 0.5801 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7448.067 | 0.3889 | 0.4353 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7448.067 | 0.0064 | -0.6605 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7449.067 | 1.0326 | 1.0327 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7449.067 | 1.0035 | 1.0035 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7449.067 | 1.0270 | 1.0272 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7449.067 | 1.0010 | 1.0010 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7449.067 | 0.5523 | 0.4812 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7449.067 | 0.5369 | 0.4601 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7449.067 | 0.5722 | 0.5079 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7449.067 | 0.4229 | 0.2941 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7449.067 | 0.0016 | -0.9224 | 1.9771 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7450.067 | 1.0244 | 1.0216 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7450.067 | 1.0537 | 1.0472 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7450.067 | 1.1188 | 1.1027 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7450.067 | 0.8920 | 0.9006 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7450.067 | 0.1581 | -0.1217 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7450.067 | 0.1922 | -0.0417 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7450.067 | 0.1585 | -0.1205 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7450.067 | 0.1118 | -0.2474 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7450.067 | 0.0041 | -0.8269 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7451.067 | 1.0082 | 1.0080 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7451.067 | 0.9877 | 0.9880 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7451.067 | 0.9823 | 0.9827 | 2.0570 |