Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 11851.161 | 0.9429 | 0.9207 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 11851.161 | 1.0082 | 1.0113 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 11851.161 | 1.0055 | 1.0076 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 11851.161 | 0.9898 | 0.9859 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 11851.161 | 0.9412 | 0.9182 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 11851.161 | 0.9147 | 0.8808 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 11851.161 | 0.8640 | 0.8084 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 11851.161 | 0.3839 | 0.0342 | 1.4516 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10875.149 | 1.0065 | 1.0176 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 10875.149 | 1.0478 | 1.1290 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 10875.149 | 1.0024 | 1.0064 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 10875.149 | 1.0178 | 1.0479 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 10875.149 | 0.9098 | 0.7621 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 10875.149 | 0.9685 | 0.9160 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 10875.149 | 0.8316 | 0.5624 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 10875.149 | 0.9958 | 0.9889 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 10875.149 | 0.5092 | -0.1898 | 0.7469 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12428.166 | 0.9808 | 0.9535 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 12428.166 | 1.0060 | 1.0146 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 12428.166 | 1.0126 | 1.0307 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 12428.166 | 1.0352 | 1.0860 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 12428.166 | 0.9926 | 0.9819 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 12428.166 | 0.9973 | 0.9934 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 12428.166 | 0.9168 | 0.7994 | 0.8223 | |
| SUM1315MO2 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 12428.166 | 0.9473 | 0.8726 | 0.8223 |