Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7477.067 | 1.3155 | 1.9955 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7477.067 | 1.8785 | 4.0635 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7477.067 | 1.3626 | 2.1550 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7477.067 | 1.1285 | 1.3898 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7477.067 | 0.3670 | -0.5433 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7477.067 | 0.3105 | -0.6429 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7477.067 | 0.3339 | -0.6027 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7477.067 | 0.3919 | -0.4970 | 0.6787 | |
| LY2 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7477.067 | 0.0016 | -0.9999 | 0.6787 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7482.067 | 0.9429 | 0.9401 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7482.067 | 0.7543 | 0.7288 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7482.067 | 0.8814 | 0.8737 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7482.067 | 0.5342 | 0.4465 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7482.067 | 0.0149 | -0.7723 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 0.267 | uM | 7482.067 | 0.0450 | -0.5973 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 1.33 | uM | 7482.067 | 0.0419 | -0.6118 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 6.67 | uM | 7482.067 | 0.0070 | -0.8465 | 1.9350 | |
| MB 157 | Unknown | Unknown | Ispinesib | KSP | Kinesin | 33.3 | uM | 7482.067 | 0.0026 | -0.9081 | 1.9350 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7483.067 | 1.0205 | 1.0124 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7483.067 | 1.0787 | 1.0466 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7483.067 | 0.9772 | 0.9861 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7483.067 | 0.9642 | 0.9780 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7483.067 | 0.1809 | 0.1893 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7483.067 | 0.1304 | 0.0766 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7483.067 | 0.1247 | 0.0621 | 3.2893 |