Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11938.157 | 0.8114 | 0.4835 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11938.157 | 0.7852 | 0.4155 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11938.157 | 0.8805 | 0.6674 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11938.157 | 0.8299 | 0.5321 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11938.157 | 0.8782 | 0.6611 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11938.157 | 0.8403 | 0.5597 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11938.157 | 0.8655 | 0.6268 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11938.157 | 0.7981 | 0.4489 | 0.6995 | |
| UACC-812 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11938.157 | 0.7563 | 0.3417 | 0.6995 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 11660.151 | 0.9424 | 0.8786 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 11660.151 | 0.9059 | 0.8020 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 11660.151 | 0.9830 | 0.9642 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 11660.151 | 0.9747 | 0.9466 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 11660.151 | 0.9652 | 0.9266 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 11660.151 | 0.8672 | 0.7209 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 11660.151 | 0.8905 | 0.7699 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 11660.151 | 0.8313 | 0.6460 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 11660.151 | 0.8578 | 0.7013 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12003.157 | 0.8874 | 0.7893 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12003.157 | 0.8604 | 0.7384 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12003.157 | 1.0083 | 1.0155 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12003.157 | 0.8838 | 0.7825 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12003.157 | 0.8588 | 0.7355 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12003.157 | 0.7854 | 0.5968 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12003.157 | 0.6999 | 0.4341 | 1.0729 |