Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10818.151 | 1.0095 | 1.0428 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10818.151 | 1.0088 | 1.0397 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10818.151 | 1.0303 | 1.1386 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10818.151 | 0.9810 | 0.9156 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10818.151 | 0.9895 | 0.9530 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10818.151 | 0.9567 | 0.8111 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10818.151 | 0.9502 | 0.7835 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12126.157 | 0.9346 | 0.8287 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12126.157 | 0.8950 | 0.7270 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12126.157 | 0.9631 | 0.9030 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12126.157 | 0.9165 | 0.7821 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12126.157 | 0.9322 | 0.8225 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12126.157 | 0.8865 | 0.7052 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12126.157 | 0.8766 | 0.6802 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12126.157 | 0.8918 | 0.7186 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12126.157 | 0.9150 | 0.7781 | 0.7555 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10643.139 | 0.9578 | 0.8696 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10643.139 | 1.0306 | 1.0964 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10643.139 | 0.9863 | 0.9575 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10643.139 | 1.0171 | 1.0538 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10643.139 | 1.0193 | 1.0605 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10643.139 | 1.0342 | 1.1078 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10643.139 | 0.9691 | 0.9042 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10643.139 | 0.9162 | 0.7444 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10643.139 | 0.9264 | 0.7748 | 0.6402 |