Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12206.157 | 0.9450 | 0.8875 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12206.157 | 0.9591 | 0.9164 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12206.157 | 0.8733 | 0.7409 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12206.157 | 0.8477 | 0.6887 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12206.157 | 0.7476 | 0.4849 | 0.9766 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 12594.171 | 0.9993 | 0.9988 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 12594.171 | 1.0361 | 1.0610 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 12594.171 | 1.0162 | 1.0274 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 12594.171 | 0.9497 | 0.9144 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 12594.171 | 0.9805 | 0.9670 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 12594.171 | 0.8887 | 0.8096 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 12594.171 | 0.8065 | 0.6667 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 12594.171 | 0.7387 | 0.5471 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 12594.171 | 0.6286 | 0.3493 | 1.1797 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10642.139 | 0.9314 | 0.8073 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10642.139 | 0.9713 | 0.9187 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10642.139 | 1.0036 | 1.0102 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10642.139 | 0.9989 | 0.9969 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10642.139 | 1.0047 | 1.0135 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10642.139 | 0.9736 | 0.9252 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10642.139 | 0.9546 | 0.8720 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10642.139 | 0.9885 | 0.9672 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10642.139 | 0.9623 | 0.8934 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10818.151 | 0.9904 | 0.9571 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10818.151 | 0.9708 | 0.8713 | 0.4459 |