Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11936.157 | 0.9709 | 0.9363 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11936.157 | 0.9243 | 0.8349 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11936.157 | 0.9295 | 0.8461 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11936.157 | 0.8645 | 0.7052 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11936.157 | 0.8848 | 0.7493 | 0.9133 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10872.151 | 0.9608 | 0.9438 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10872.151 | 1.0083 | 1.0118 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10872.151 | 1.0009 | 1.0012 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10872.151 | 0.9848 | 0.9783 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10872.151 | 0.9869 | 0.9813 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10872.151 | 0.9620 | 0.9456 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10872.151 | 0.8165 | 0.7309 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10872.151 | 0.7625 | 0.6485 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10872.151 | 0.7853 | 0.6835 | 1.4028 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12523.157 | 0.9357 | 0.8679 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12523.157 | 0.9729 | 0.9443 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12523.157 | 0.9679 | 0.9339 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12523.157 | 0.9716 | 0.9416 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12523.157 | 0.9300 | 0.8563 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12523.157 | 0.8987 | 0.7921 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 12523.157 | 0.7872 | 0.5640 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 12523.157 | 0.7679 | 0.5245 | 0.9728 | |
| HCC1569 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 12523.157 | 0.8095 | 0.6095 | 0.9728 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12239.157 | 1.0309 | 1.0293 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12239.157 | 0.9540 | 0.9556 | 2.0946 |