Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 12084.157 | 1.0000 | 1.0000 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 12084.157 | 0.8512 | 0.7746 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 12084.157 | 0.7843 | 0.6700 | 1.3475 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12001.157 | 0.9211 | 0.7402 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12001.157 | 0.9291 | 0.7657 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12001.157 | 0.9920 | 0.9730 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12001.157 | 0.9143 | 0.7184 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12001.157 | 0.9187 | 0.7323 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12001.157 | 0.9579 | 0.8594 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12001.157 | 0.9442 | 0.8146 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12001.157 | 0.9214 | 0.7411 | 0.5904 | |
| HCC1419 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12001.157 | 0.9129 | 0.7140 | 0.5904 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10693.151 | 0.9707 | 0.9382 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10693.151 | 0.9593 | 0.9141 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10693.151 | 0.9775 | 0.9525 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10693.151 | 1.0051 | 1.0108 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10693.151 | 0.9951 | 0.9898 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10693.151 | 0.9905 | 0.9800 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10693.151 | 0.9654 | 0.9271 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10693.151 | 0.9492 | 0.8929 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10693.151 | 0.9586 | 0.9127 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11936.157 | 0.8899 | 0.7601 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11936.157 | 0.8954 | 0.7721 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11936.157 | 0.9186 | 0.8224 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11936.157 | 0.9283 | 0.8436 | 0.9133 |