Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10518.139 | 0.3394 | -0.1654 | 1.2366 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10753.151 | 0.9706 | 0.9514 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10753.151 | 1.0011 | 1.0018 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10753.151 | 0.9342 | 0.8909 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10753.151 | 0.9856 | 0.9763 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10753.151 | 1.0050 | 1.0082 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10753.151 | 0.7919 | 0.6503 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10753.151 | 0.6712 | 0.4400 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10753.151 | 0.4029 | -0.0542 | 1.2139 | |
| HCC1187 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10753.151 | 0.3052 | -0.2477 | 1.2139 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12000.157 | 0.9781 | 0.9432 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12000.157 | 0.9389 | 0.8422 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12000.157 | 1.0034 | 1.0089 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12000.157 | 0.9440 | 0.8551 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12000.157 | 0.9687 | 0.9187 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12000.157 | 0.9000 | 0.7433 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 12000.157 | 0.8392 | 0.5914 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 12000.157 | 0.8226 | 0.5505 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 12000.157 | 0.6286 | 0.0919 | 0.7671 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12084.157 | 1.0602 | 1.0887 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12084.157 | 1.0334 | 1.0494 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12084.157 | 0.9972 | 0.9959 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12084.157 | 0.9933 | 0.9901 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12084.157 | 1.0747 | 1.1098 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12084.157 | 0.9170 | 0.8754 | 1.3475 |