Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12239.157 | 0.9777 | 0.9786 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12239.157 | 0.9701 | 0.9712 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12239.157 | 0.9344 | 0.9363 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12239.157 | 0.8380 | 0.8382 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 12239.157 | 0.7012 | 0.6883 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 12239.157 | 0.7372 | 0.7290 | 2.0946 | |
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 12239.157 | 0.6602 | 0.6404 | 2.0946 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11849.157 | 0.9360 | 0.9112 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11849.157 | 0.9437 | 0.9219 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11849.157 | 0.9773 | 0.9687 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11849.157 | 0.9201 | 0.8888 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11849.157 | 1.0565 | 1.0769 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11849.157 | 0.8989 | 0.8589 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 11849.157 | 0.8594 | 0.8023 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 11849.157 | 0.8274 | 0.7560 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 11849.157 | 0.9310 | 0.9041 | 1.4559 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 11055.151 | 0.8693 | 0.8572 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 11055.151 | 0.9271 | 0.9215 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 11055.151 | 0.9261 | 0.9204 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 11055.151 | 0.9109 | 0.9037 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 11055.151 | 0.8969 | 0.8882 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 11055.151 | 0.8010 | 0.7786 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 11055.151 | 0.7620 | 0.7323 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 11055.151 | 0.7267 | 0.6894 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 11055.151 | 0.5600 | 0.4720 | 1.8913 |