Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10999.151 | 0.9314 | 0.8091 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10999.151 | 1.0375 | 1.1065 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10999.151 | 0.9387 | 0.8293 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10999.151 | 1.0051 | 1.0143 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10999.151 | 0.9901 | 0.9722 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10999.151 | 0.9782 | 0.9387 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10999.151 | 1.0414 | 1.1179 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10999.151 | 0.8826 | 0.6771 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10999.151 | 0.9605 | 0.8896 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12379.157 | 1.0701 | 1.2961 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12379.157 | 1.1228 | 1.5322 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12379.157 | 1.0822 | 1.3492 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12379.157 | 1.0619 | 1.2603 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12379.157 | 1.0594 | 1.2495 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12379.157 | 1.0447 | 1.1864 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12379.157 | 1.0413 | 1.1718 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12379.157 | 0.9823 | 0.9284 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12379.157 | 0.8280 | 0.3618 | 0.4910 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10938.151 | 0.8677 | 0.7527 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10938.151 | 0.8738 | 0.7640 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10938.151 | 0.9437 | 0.8950 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10938.151 | 0.9334 | 0.8758 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10938.151 | 0.7642 | 0.5573 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10938.151 | 0.9006 | 0.8143 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10938.151 | 0.9334 | 0.8757 | 1.0747 |