Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10938.151 | 0.8405 | 0.7015 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10938.151 | 0.6587 | 0.3561 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12333.157 | 0.9257 | 0.8066 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12333.157 | 0.8884 | 0.7112 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12333.157 | 0.9016 | 0.7450 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12333.157 | 0.8653 | 0.6530 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12333.157 | 0.8685 | 0.6610 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12333.157 | 0.8466 | 0.6060 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12333.157 | 0.7887 | 0.4630 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12333.157 | 0.8065 | 0.5067 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12333.157 | 0.6595 | 0.1558 | 0.7591 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12414.157 | 0.9770 | 0.9557 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12414.157 | 0.9634 | 0.9296 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12414.157 | 0.9520 | 0.9075 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12414.157 | 0.9256 | 0.8567 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12414.157 | 0.9661 | 0.9347 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12414.157 | 1.0062 | 1.0119 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12414.157 | 0.9964 | 0.9930 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12414.157 | 0.9044 | 0.8156 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12414.157 | 0.6546 | 0.3303 | 1.0392 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10644.139 | 0.9393 | 0.8042 | 0.6077 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10644.139 | 0.9001 | 0.6819 | 0.6077 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10644.139 | 0.9743 | 0.9163 | 0.6077 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10644.139 | 0.9874 | 0.9587 | 0.6077 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10644.139 | 1.0016 | 1.0053 | 0.6077 |