Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7530.067 | 0.1981 | -0.0835 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7530.067 | 0.2405 | 0.0063 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7530.067 | 0.0337 | -0.6097 | 2.0748 | |
| SUM149PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7530.067 | 0.0033 | -0.8720 | 2.0748 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7531.067 | 0.9506 | 0.9721 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7531.067 | 0.9033 | 0.9444 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7531.067 | 1.0130 | 1.0072 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7531.067 | 1.0415 | 1.0227 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7531.067 | 0.3041 | 0.4377 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.267 | uM | 7531.067 | 0.1775 | 0.2384 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7531.067 | 0.1867 | 0.2558 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7531.067 | 0.0087 | -0.4634 | 3.6061 | |
| SUM159PT | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7531.067 | 0.0005 | -0.7605 | 3.6061 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7532.067 | 0.9869 | 0.9731 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7532.067 | 0.9427 | 0.8825 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7532.067 | 0.9776 | 0.9541 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7532.067 | 0.9708 | 0.9400 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7532.067 | 0.7311 | 0.4502 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7532.067 | 0.5812 | 0.1460 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7532.067 | 0.5847 | 0.1531 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7532.067 | 0.1497 | -0.7152 | 0.9744 | |
| SUM185PE | TNBC | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7532.067 | 0.0061 | -0.9893 | 0.9744 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7533.067 | 1.0652 | 1.1234 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7533.067 | 1.0470 | 1.0889 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7533.067 | 1.0217 | 1.0412 | 1.0554 |