Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7533.067 | 1.0034 | 1.0065 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7533.067 | 0.6476 | 0.3251 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7533.067 | 0.5604 | 0.1554 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7533.067 | 0.5749 | 0.1837 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7533.067 | 0.4033 | -0.1540 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7533.067 | 0.0020 | -0.9946 | 1.0554 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7534.067 | 1.0711 | 1.1256 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7534.067 | 0.9937 | 0.9888 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7534.067 | 0.9708 | 0.9481 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7534.067 | 0.9347 | 0.8838 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7534.067 | 0.6189 | 0.3069 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7534.067 | 0.6206 | 0.3101 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7534.067 | 0.5921 | 0.2566 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7534.067 | 0.2283 | -0.4604 | 1.1276 | |
| SUM225CWN | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7534.067 | 0.0004 | -0.9982 | 1.1276 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7537.067 | 0.9758 | 0.9754 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7537.067 | 0.9508 | 0.9496 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7537.067 | 0.9643 | 0.9636 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7537.067 | 0.9366 | 0.9349 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7537.067 | 0.3201 | 0.1242 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 0.267 | uM | 7537.067 | 0.2732 | 0.0376 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 1.33 | uM | 7537.067 | 0.2520 | -0.0039 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 6.67 | uM | 7537.067 | 0.0462 | -0.5779 | 1.9773 | |
| SUM229PE | TNBC | - | Ispinesib | KSP | Kinesin | 33.3 | uM | 7537.067 | 0.0031 | -0.8917 | 1.9773 | |
| SUM52PE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7541.067 | 0.9469 | 0.9259 | 1.4459 |