Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10996.151 | 0.9530 | 0.8093 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10996.151 | 0.9833 | 0.9309 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10996.151 | 0.9743 | 0.8945 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10996.151 | 0.9535 | 0.8112 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10996.151 | 0.9705 | 0.8791 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10996.151 | 0.9242 | 0.6972 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10996.151 | 0.8708 | 0.4994 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10996.151 | 0.7733 | 0.1708 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10996.151 | 0.7863 | 0.2121 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12192.157 | 1.0783 | 1.2791 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12192.157 | 0.9911 | 0.9693 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12192.157 | 0.9699 | 0.8969 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12192.157 | 1.0401 | 1.1411 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12192.157 | 1.0173 | 1.0603 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12192.157 | 0.8771 | 0.5937 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 12192.157 | 0.9024 | 0.6742 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12192.157 | 0.7280 | 0.1540 | 0.5774 | |
| HCC2185 | TNBC | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12192.157 | 0.7952 | 0.3448 | 0.5774 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10577.139 | 0.9618 | 0.9174 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10577.139 | 0.9870 | 0.9719 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10577.139 | 0.9428 | 0.8764 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10577.139 | 1.0649 | 1.1409 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10577.139 | 1.0550 | 1.1193 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10577.139 | 1.0250 | 1.0541 | 0.9234 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10577.139 | 0.9525 | 0.8973 | 0.9234 |