Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 12003.157 | 0.7091 | 0.4517 | 1.0729 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 12003.157 | 0.6920 | 0.4190 | 1.0729 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11939.157 | 0.9432 | 0.9278 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11939.157 | 0.9967 | 0.9959 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11939.157 | 0.9694 | 0.9612 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11939.157 | 0.9285 | 0.9089 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11939.157 | 0.8534 | 0.8103 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11939.157 | 0.6056 | 0.4592 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11939.157 | 0.6217 | 0.4834 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11939.157 | 0.5679 | 0.4014 | 1.5908 | |
| ZR75B | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11939.157 | 0.6036 | 0.4562 | 1.5908 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.000171 | uM | 5895.093 | 1.0885 | 1.1321 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.000853 | uM | 5895.093 | 1.0387 | 1.0581 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.00427 | uM | 5895.093 | 1.0370 | 1.0556 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.0213 | uM | 5895.093 | 1.0873 | 1.1303 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.107 | uM | 5895.093 | 1.0465 | 1.0698 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 0.533 | uM | 5895.093 | 0.7463 | 0.6039 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 2.67 | uM | 5895.093 | 0.4151 | 0.0305 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 13.3 | uM | 5895.093 | 0.0080 | -0.9477 | 1.3259 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 66.7 | uM | 5895.093 | 0.0063 | -0.9564 | 1.3259 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 0.000171 | uM | 5897.093 | 1.0297 | 1.0492 | 1.2047 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 0.000853 | uM | 5897.093 | 1.0872 | 1.1437 | 1.2047 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 0.00427 | uM | 5897.093 | 1.0467 | 1.0773 | 1.2047 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 0.0213 | uM | 5897.093 | 1.0817 | 1.1347 | 1.2047 | |
| 184B5 | NM | Basal | IKK16 | IKK | NFKB | 0.107 | uM | 5897.093 | 1.0437 | 1.0722 | 1.2047 |