Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 9648.017 | 0.9727 | 0.9055 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 9648.017 | 0.8653 | 0.5535 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 9648.017 | 0.8056 | 0.3713 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 9648.017 | 0.4813 | -0.4422 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 9648.017 | 0.2179 | -0.8602 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 9648.017 | 0.0671 | -0.9821 | 0.5727 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.0492 | uM | 7897.035 | 1.0054 | 1.0130 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 0.246 | uM | 7897.035 | 0.9567 | 0.8972 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 1.23 | uM | 7897.035 | 1.0254 | 1.0608 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 6.15 | uM | 7897.035 | 0.9726 | 0.9348 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 30.7 | uM | 7897.035 | 0.9093 | 0.7853 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 154 | uM | 7897.035 | 0.8357 | 0.6144 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 769 | uM | 7897.035 | 0.5804 | 0.0449 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 3840 | uM | 7897.035 | 0.2982 | -0.5281 | 0.8378 | |
| MDA-MB-415 | HR+ | Luminal | 5-FU | TYMS | TYMS | 19200 | uM | 7897.035 | 0.1932 | -0.7189 | 0.8378 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.0492 | uM | 7898.017 | 0.8787 | 0.7883 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.246 | uM | 7898.017 | 1.1339 | 1.2297 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 1.23 | uM | 7898.017 | 0.9265 | 0.8722 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 6.15 | uM | 7898.017 | 0.9782 | 0.9623 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 30.7 | uM | 7898.017 | 0.9635 | 0.9367 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 154 | uM | 7898.017 | 0.7676 | 0.5909 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 769 | uM | 7898.017 | 0.6446 | 0.3677 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 3840 | uM | 7898.017 | 0.5319 | 0.1582 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 19200 | uM | 7898.017 | 0.3196 | -0.2547 | 1.1556 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 0.0492 | uM | 7899.017 | 0.9629 | 0.9633 | 2.0395 |