Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10095.001 | 0.4425 | -0.1877 | 0.9049 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7897.001 | 0.9924 | 0.9797 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7897.001 | 0.9045 | 0.7483 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7897.001 | 0.9776 | 0.9402 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7897.001 | 1.0071 | 1.0190 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7897.001 | 0.6542 | 0.1330 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7897.001 | 0.6070 | 0.0249 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7897.001 | 0.5967 | 0.0016 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7897.001 | 0.5598 | -0.0804 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7897.001 | 0.1319 | -0.8674 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9664.001 | 0.9323 | 0.8321 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9664.001 | 0.9967 | 0.9918 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9664.001 | 1.0304 | 1.0765 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9664.001 | 1.0312 | 1.0783 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9664.001 | 0.8967 | 0.7451 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9664.001 | 0.5440 | -0.0661 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9664.001 | 0.5713 | -0.0072 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9664.001 | 0.5455 | -0.0630 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9664.001 | 0.2197 | -0.6996 | 0.7994 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7898.001 | 1.0752 | 1.1211 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7898.001 | 0.8003 | 0.6695 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7898.001 | 1.0828 | 1.1332 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7898.001 | 0.8472 | 0.7485 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7898.001 | 0.4768 | 0.0973 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7898.001 | 0.3926 | -0.0627 | 1.2337 |