Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10146.001 | 0.8833 | 0.6895 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10146.001 | 0.8486 | 0.5999 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10146.001 | 0.8567 | 0.6209 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10146.001 | 0.8863 | 0.6973 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10146.001 | 0.5679 | -0.0731 | 0.7356 | |
| SUM185PE | TNBC | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10146.001 | 0.0503 | -0.9656 | 0.7356 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9860.001 | 0.9809 | 0.9762 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9860.001 | 1.0461 | 1.0567 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9860.001 | 0.9453 | 0.9314 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9860.001 | 0.8861 | 0.8555 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9860.001 | 0.3694 | 0.0783 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 0.267 | uM | 9860.001 | 0.4389 | 0.2000 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 1.33 | uM | 9860.001 | 0.4703 | 0.2524 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 6.67 | uM | 9860.001 | 0.3847 | 0.1057 | 1.6119 | |
| SUM229PE | TNBC | - | GSK461364 | PLK1 | PLK | 33.3 | uM | 9860.001 | 0.2206 | -0.2168 | 1.6119 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9878.001 | 0.9556 | 0.9333 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9878.001 | 0.9694 | 0.9542 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9878.001 | 0.8907 | 0.8344 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9878.001 | 0.4998 | 0.1912 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9878.001 | 0.2598 | -0.2693 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9878.001 | 0.3488 | -0.0894 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9878.001 | 0.4489 | 0.0995 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9878.001 | 0.3253 | -0.1357 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9878.001 | 0.2589 | -0.2712 | 1.3386 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9889.001 | 0.9863 | 0.9813 | 1.4638 |