Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7527.098 | 0.9905 | 0.9890 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7527.098 | 0.9238 | 0.9103 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7527.098 | 0.7545 | 0.6989 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7527.098 | 0.0526 | -0.6369 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7527.098 | 0.0175 | -0.8083 | 1.7263 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 7528.071 | 1.2734 | 2.0278 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00154 | uM | 7528.071 | 1.2549 | 1.9529 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00768 | uM | 7528.071 | 1.2301 | 1.8533 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0384 | uM | 7528.071 | 1.2552 | 1.9541 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.192 | uM | 7528.071 | 1.2023 | 1.7436 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.96 | uM | 7528.071 | 1.1156 | 1.4129 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 4.8 | uM | 7528.071 | 1.1147 | 1.4096 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 24 | uM | 7528.071 | 1.0770 | 1.2714 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 120 | uM | 7528.071 | 1.0554 | 1.1940 | 0.5828 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7528.091 | 0.9807 | 0.9591 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7528.091 | 0.9846 | 0.9673 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7528.091 | 0.9648 | 0.9253 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7528.091 | 0.9723 | 0.9412 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7528.091 | 0.9705 | 0.9374 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7528.091 | 0.7943 | 0.5663 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7528.091 | 0.8342 | 0.6499 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7528.091 | 0.0086 | -0.9872 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 133 | uM | 7528.091 | 0.7369 | 0.4463 | 0.9421 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7528.098 | 1.0527 | 1.1085 | 0.9717 | |
| SUM1315MO2 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7528.098 | 1.0512 | 1.1055 | 0.9717 |