Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7504.098 | 1.1627 | 1.1655 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7504.098 | 1.0119 | 1.0126 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7504.098 | 0.9173 | 0.9110 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7504.098 | 1.1274 | 1.1306 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7504.098 | 1.0340 | 1.0355 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7504.098 | 0.9911 | 0.9906 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7504.098 | 0.0193 | -0.7509 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7504.098 | 0.0130 | -0.7973 | 1.8959 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7505.09 | 1.0232 | 1.0741 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7505.09 | 1.0291 | 1.0931 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7505.09 | 1.0082 | 1.0262 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7505.09 | 1.0023 | 1.0073 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7505.09 | 0.7075 | 0.1544 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7505.09 | 0.5703 | -0.1803 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7505.09 | 0.6738 | 0.0682 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7505.09 | 0.6955 | 0.1235 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7505.09 | 0.6995 | 0.1336 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7506.091 | 1.0944 | 1.1694 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7506.091 | 0.9547 | 0.9181 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7506.091 | 0.9474 | 0.9049 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7506.091 | 1.0306 | 1.0550 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7506.091 | 0.9705 | 0.9467 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7506.091 | 0.9542 | 0.9172 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7506.091 | 0.9592 | 0.9263 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7506.091 | 0.0188 | -0.9444 | 1.1096 |