Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7475.098 | 1.0359 | 1.0310 | 2.2876 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7475.098 | 1.1076 | 1.0914 | 2.2876 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7475.098 | 1.3550 | 1.2840 | 2.2876 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7475.098 | 0.4375 | 0.3935 | 2.2876 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7475.098 | 0.0886 | -0.3065 | 2.2876 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 10379.092 | 0.9222 | 0.9382 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 10379.092 | 0.9023 | 0.9219 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 10379.092 | 0.9202 | 0.9366 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 10379.092 | 0.9463 | 0.9577 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.107 | uM | 10379.092 | 0.9574 | 0.9665 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 0.533 | uM | 10379.092 | 0.9640 | 0.9718 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 2.67 | uM | 10379.092 | 0.9235 | 0.9392 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 13.3 | uM | 10379.092 | 0.8671 | 0.8925 | 2.5811 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 66.7 | uM | 10379.092 | 0.9400 | 0.9526 | 2.5811 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 7477.071 | 0.9674 | 0.8748 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00154 | uM | 7477.071 | 1.2483 | 2.0836 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00768 | uM | 7477.071 | 1.4512 | 3.1378 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0384 | uM | 7477.071 | 1.8035 | 5.3252 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.192 | uM | 7477.071 | 1.1366 | 1.5682 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.96 | uM | 7477.071 | 0.7547 | 0.1544 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 4.8 | uM | 7477.071 | 0.4378 | -0.6013 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 24 | uM | 7477.071 | 0.0645 | -0.9905 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 120 | uM | 7477.071 | 0.0017 | -1.0000 | 0.5122 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7477.091 | 1.0396 | 1.0689 | 1.1485 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7477.091 | 1.1739 | 1.2997 | 1.1485 |