Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 4.8 | uM | 7464.071 | 0.9325 | 0.7658 | 0.5610 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 24 | uM | 7464.071 | 0.3771 | -0.6484 | 0.5610 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 120 | uM | 7464.071 | 0.5332 | -0.3482 | 0.5610 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7464.09 | 1.0258 | 1.1056 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7464.09 | 1.0335 | 1.1374 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7464.09 | 1.0790 | 1.3314 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7464.09 | 1.0548 | 1.2274 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7464.09 | 1.0476 | 1.1965 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7464.09 | 1.0394 | 1.1623 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7464.09 | 0.8259 | 0.3598 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7464.09 | 0.8727 | 0.5196 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7464.09 | 0.8668 | 0.4991 | 0.4958 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7464.098 | 0.9620 | 0.8809 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7464.098 | 1.0062 | 1.0197 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7464.098 | 0.9593 | 0.8724 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7464.098 | 0.9709 | 0.9085 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7464.098 | 0.9389 | 0.8096 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7464.098 | 0.9896 | 0.9673 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7464.098 | 0.9331 | 0.7919 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7464.098 | 0.3080 | -0.6911 | 0.6305 | |
| HCC2185 | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7464.098 | 0.2214 | -0.8170 | 0.6305 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7465.092 | 0.9801 | 0.9669 | 1.2055 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7465.092 | 0.8629 | 0.7698 | 1.2055 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7465.092 | 0.9051 | 0.8411 | 1.2055 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7465.092 | 0.9742 | 0.9571 | 1.2055 |