Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9933.001 | 0.3951 | -0.7408 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9933.001 | 0.3880 | -0.7509 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9933.001 | 0.4835 | -0.5960 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9933.001 | 0.5430 | -0.4782 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9933.001 | 0.5040 | -0.5571 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9953.001 | 0.9803 | 0.8855 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9953.001 | 1.1782 | 2.2508 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9953.001 | 0.9576 | 0.7589 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9953.001 | 0.9601 | 0.7729 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9953.001 | 0.5199 | -0.7118 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9953.001 | 0.5416 | -0.6747 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9953.001 | 0.5911 | -0.5785 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9953.001 | 0.6787 | -0.3655 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9953.001 | 0.4610 | -0.7981 | 0.3377 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7931.001 | 0.9845 | 0.9760 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7931.001 | 1.0542 | 1.0836 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7931.001 | 1.0094 | 1.0146 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7931.001 | 1.0335 | 1.0518 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7931.001 | 0.9376 | 0.9026 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7931.001 | 0.5763 | 0.3046 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7931.001 | 0.8268 | 0.7258 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7931.001 | 0.9091 | 0.8575 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7931.001 | 0.5049 | 0.1775 | 1.2900 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7932.001 | 1.0544 | 1.1060 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7932.001 | 1.0654 | 1.1274 | 1.0256 |