Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10151.001 | 0.9925 | 0.9645 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10151.001 | 0.9353 | 0.7062 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10151.001 | 0.0519 | -0.9982 | 0.4212 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10267.001 | 1.0129 | 1.0657 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10267.001 | 1.2794 | 2.7278 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10267.001 | 1.0226 | 1.1163 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10267.001 | 1.1807 | 2.0432 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10267.001 | 0.8483 | 0.3195 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10267.001 | 1.2110 | 2.2448 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10267.001 | 1.1130 | 1.6217 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10267.001 | 0.8966 | 0.5179 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10267.001 | 0.4052 | -0.7961 | 0.3957 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9045.001 | 1.0160 | 1.0330 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9045.001 | 1.1556 | 1.3209 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9045.001 | 0.7280 | 0.4426 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9045.001 | 0.3259 | -0.3689 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9045.001 | 0.2951 | -0.4303 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9045.001 | 0.3061 | -0.4084 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9045.001 | 0.5203 | 0.0211 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9045.001 | 0.5382 | 0.0574 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9045.001 | 0.4108 | -0.1993 | 0.9719 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9933.001 | 0.9288 | 0.7001 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9933.001 | 1.0932 | 1.4332 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9933.001 | 0.9620 | 0.8365 | 0.4544 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9933.001 | 0.7722 | 0.1323 | 0.4544 |