Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7932.001 | 1.0386 | 1.0752 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7932.001 | 0.9830 | 0.9668 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7932.001 | 0.9423 | 0.8873 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7932.001 | 0.6173 | 0.2496 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7932.001 | 0.9734 | 0.9481 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7932.001 | 1.0797 | 1.1553 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7932.001 | 0.3438 | -0.2938 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9958.001 | 0.9997 | 0.9988 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9958.001 | 0.9859 | 0.9457 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9958.001 | 0.9943 | 0.9780 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9958.001 | 0.9833 | 0.9357 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9958.001 | 0.7361 | 0.1051 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9958.001 | 0.7145 | 0.0429 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9958.001 | 0.9845 | 0.9402 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9958.001 | 0.8614 | 0.4981 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9958.001 | 0.4155 | -0.6349 | 0.5164 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9972.001 | 1.0017 | 1.0032 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9972.001 | 1.0272 | 1.0517 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9972.001 | 1.0049 | 1.0092 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9972.001 | 1.0863 | 1.1638 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9972.001 | 0.8053 | 0.6279 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9972.001 | 0.5587 | 0.1500 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9972.001 | 0.6108 | 0.2517 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9972.001 | 0.6371 | 0.3030 | 1.0521 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9972.001 | 0.5320 | 0.0977 | 1.0521 |