Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7444.091 | 0.1435 | -0.7818 | 0.8764 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7444.098 | 0.9499 | 0.8965 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7444.098 | 0.9008 | 0.7953 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7444.098 | 0.9374 | 0.8709 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7444.098 | 0.9514 | 0.8996 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7444.098 | 0.9027 | 0.7993 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7444.098 | 0.8310 | 0.6518 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7444.098 | 0.3915 | -0.2409 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7444.098 | 0.1339 | -0.7494 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7444.098 | 0.3718 | -0.2802 | 0.9681 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7447.09 | 0.9803 | 0.9750 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7447.09 | 0.9371 | 0.9197 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7447.09 | 0.9248 | 0.9038 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7447.09 | 0.9508 | 0.9374 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7447.09 | 0.9498 | 0.9361 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7447.09 | 0.8500 | 0.8053 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7447.09 | 0.7393 | 0.6532 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7447.09 | 0.5235 | 0.3300 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 133 | uM | 7447.09 | 0.3100 | -0.0442 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7448.098 | 1.0164 | 1.0113 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7448.098 | 0.9853 | 0.9898 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7448.098 | 1.0078 | 1.0054 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7448.098 | 1.0326 | 1.0223 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7448.098 | 0.9816 | 0.9872 | 2.8877 | |
| HCC1569 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7448.098 | 0.9470 | 0.9627 | 2.8877 |