Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7457.09 | 0.9694 | 0.9646 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7457.09 | 0.9866 | 0.9846 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7457.09 | 0.9407 | 0.9309 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7457.09 | 0.9642 | 0.9585 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7457.09 | 0.9377 | 0.9274 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 133 | uM | 7457.09 | 0.9239 | 0.9111 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7457.098 | 0.9218 | 0.9131 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7457.098 | 0.9113 | 0.9012 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7457.098 | 1.0023 | 1.0025 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7457.098 | 1.0547 | 1.0589 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7457.098 | 0.9694 | 0.9664 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7457.098 | 0.9741 | 0.9715 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7457.098 | 0.9285 | 0.9206 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7457.098 | 0.5670 | 0.4674 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7457.098 | 0.0273 | -0.7200 | 1.8323 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7458.091 | 0.9910 | 0.9673 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7458.091 | 1.0135 | 1.0493 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7458.091 | 0.6897 | 0.0178 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7458.091 | 0.9634 | 0.8689 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7458.091 | 0.9374 | 0.7782 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7458.091 | 0.9242 | 0.7329 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7458.091 | 0.9936 | 0.9766 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7458.091 | 1.0001 | 1.0005 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 133 | uM | 7458.091 | 1.0201 | 1.0736 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7458.098 | 1.0288 | 1.1014 | 0.5731 |