Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0107 | uM | 10261.001 | 0.9149 | 0.9257 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0533 | uM | 10261.001 | 0.8425 | 0.8592 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.267 | uM | 10261.001 | 0.8486 | 0.8649 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 1.33 | uM | 10261.001 | 0.7564 | 0.7757 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 6.67 | uM | 10261.001 | 0.2617 | 0.1298 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 33.3 | uM | 10261.001 | 0.0004 | -0.9301 | 2.3472 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9210.001 | 1.0305 | 1.0699 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9210.001 | 0.9495 | 0.8852 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9210.001 | 1.0090 | 1.0206 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9210.001 | 0.9353 | 0.8531 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9210.001 | 0.9621 | 0.9137 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9210.001 | 0.9252 | 0.8302 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9210.001 | 0.9360 | 0.8546 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9210.001 | 0.8355 | 0.6291 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9210.001 | 0.3302 | -0.4354 | 0.8761 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7808.001 | 1.0362 | 1.0283 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.000427 | uM | 7808.001 | 1.0038 | 1.0030 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.00213 | uM | 7808.001 | 0.9852 | 0.9882 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.0107 | uM | 7808.001 | 0.5997 | 0.6343 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.0533 | uM | 7808.001 | 0.6435 | 0.6804 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.267 | uM | 7808.001 | 0.4024 | 0.3960 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 1.33 | uM | 7808.001 | 0.2983 | 0.2404 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 6.67 | uM | 7808.001 | 0.0188 | -0.5833 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 33.3 | uM | 7808.001 | 0.0005 | -0.9041 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9226.001 | 0.9845 | 0.9882 | 2.6569 |