Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9163.001 | 0.9104 | 0.6712 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9163.001 | 0.9524 | 0.8220 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9163.001 | 0.6725 | -0.0639 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9163.001 | 0.1344 | -0.9570 | 0.5227 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7801.001 | 0.9921 | 0.9708 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 7801.001 | 1.0637 | 1.2423 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 7801.001 | 1.0049 | 1.0181 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 7801.001 | 0.9376 | 0.7752 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 7801.001 | 0.9850 | 0.9449 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 7801.001 | 0.9799 | 0.9262 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 7801.001 | 0.8755 | 0.5637 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 7801.001 | 0.8321 | 0.4231 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 7801.001 | 0.4243 | -0.5910 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9186.001 | 1.0777 | 1.3117 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.000427 | uM | 9186.001 | 0.9666 | 0.8725 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.00213 | uM | 9186.001 | 1.0491 | 1.1945 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0107 | uM | 9186.001 | 0.9371 | 0.7636 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.0533 | uM | 9186.001 | 1.0091 | 1.0356 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 0.267 | uM | 9186.001 | 0.9697 | 0.8842 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 1.33 | uM | 9186.001 | 0.9588 | 0.8434 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 6.67 | uM | 9186.001 | 0.8244 | 0.3762 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK1070916 | AURK | AURK | 33.3 | uM | 9186.001 | 0.5496 | -0.3723 | 0.5165 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 10261.001 | 1.1130 | 1.0934 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.000427 | uM | 10261.001 | 1.0286 | 1.0242 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.00213 | uM | 10261.001 | 1.0243 | 1.0206 | 2.3472 |