Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12333.143 | 0.5555 | -0.2174 | 0.6265 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12414.143 | 0.9080 | 0.8441 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12414.143 | 0.9611 | 0.9345 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12414.143 | 0.9882 | 0.9801 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12414.143 | 0.7246 | 0.5256 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 12414.143 | 0.6174 | 0.3336 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 12414.143 | 0.7036 | 0.4883 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 12414.143 | 0.8309 | 0.7117 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 12414.143 | 0.7434 | 0.5588 | 1.1898 | |
| MDA-MB-453 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 12414.143 | 0.4004 | -0.0733 | 1.1898 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10644.143 | 0.9647 | 0.8879 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10644.143 | 0.8897 | 0.6574 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10644.143 | 0.9561 | 0.8606 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10644.143 | 0.9583 | 0.8677 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 8 | uM | 10644.143 | 0.7850 | 0.3553 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 40 | uM | 10644.143 | 0.7719 | 0.3192 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 200 | uM | 10644.143 | 0.9167 | 0.7391 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1000 | uM | 10644.143 | 0.8057 | 0.4133 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 5000 | uM | 10644.143 | 0.3565 | -0.6190 | 0.6221 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10874.143 | 0.9779 | 0.9422 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10874.143 | 1.0120 | 1.0314 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10874.143 | 1.0499 | 1.1317 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10874.143 | 0.9556 | 0.8847 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 8 | uM | 10874.143 | 0.8597 | 0.6408 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 40 | uM | 10874.143 | 0.8964 | 0.7333 | 0.7639 |