Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 200 | uM | 10874.143 | 0.9322 | 0.8243 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1000 | uM | 10874.143 | 0.8612 | 0.6447 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 5000 | uM | 10874.143 | 0.4472 | -0.3025 | 0.7639 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 12220.143 | 0.8862 | 0.5319 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.064 | uM | 12220.143 | 0.7937 | 0.2011 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 0.32 | uM | 12220.143 | 0.8550 | 0.4156 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1.6 | uM | 12220.143 | 0.7749 | 0.1394 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 8 | uM | 12220.143 | 0.7478 | 0.0532 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 40 | uM | 12220.143 | 0.8418 | 0.3676 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 200 | uM | 12220.143 | 0.9079 | 0.6160 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 1000 | uM | 12220.143 | 0.6282 | -0.2831 | 0.4532 | |
| MX1 | Unknown | Unknown | 5-DFUR | TYMS | TYMS | 5000 | uM | 12220.143 | 0.3504 | -0.8023 | 0.4532 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 11851.143 | 0.9253 | 0.8953 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 11851.143 | 0.9357 | 0.9101 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 11851.143 | 0.8641 | 0.8077 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 11851.143 | 0.9024 | 0.8628 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 11851.143 | 0.8033 | 0.7186 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 11851.143 | 0.7829 | 0.6883 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 11851.143 | 0.6938 | 0.5529 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 11851.143 | 0.6225 | 0.4406 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 11851.143 | 0.3917 | 0.0454 | 1.4447 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10875.143 | 0.9622 | 0.9083 | 0.8219 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10875.143 | 0.9947 | 0.9870 | 0.8219 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10875.143 | 1.0176 | 1.0429 | 0.8219 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10875.143 | 1.0159 | 1.0389 | 0.8219 |