Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10262.012 | 0.2561 | -0.8089 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10262.012 | 0.2860 | -0.7688 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10262.012 | 0.3119 | -0.7314 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10262.012 | 0.2834 | -0.7724 | 0.5802 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9386.012 | 0.9898 | 0.9855 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9386.012 | 1.1042 | 1.1453 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9386.012 | 0.8556 | 0.7911 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9386.012 | 0.2443 | -0.2619 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9386.012 | 0.2486 | -0.2527 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9386.012 | 0.2364 | -0.2788 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9386.012 | 0.2500 | -0.2496 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9386.012 | 0.2207 | -0.3131 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9386.012 | 0.1902 | -0.3816 | 1.4141 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7844.012 | 0.9550 | 0.8020 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7844.012 | 0.9708 | 0.8700 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7844.012 | 0.9578 | 0.8137 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7844.012 | 0.7060 | -0.0910 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7844.012 | 0.5582 | -0.4660 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7844.012 | 0.4708 | -0.6369 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7844.012 | 0.4807 | -0.6193 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7844.012 | 0.3933 | -0.7583 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7844.012 | 0.4332 | -0.6993 | 0.4416 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7849.04 | 0.9914 | 0.9686 | 0.5448 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7849.04 | 1.0216 | 1.0798 | 0.5448 | |
| HCC2185 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7849.04 | 0.9927 | 0.9731 | 0.5448 |