Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9163.024 | 0.2427 | -0.8460 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9163.024 | 0.2357 | -0.8538 | 0.5524 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7801.012 | 1.0258 | 1.0931 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7801.012 | 0.9715 | 0.8994 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7801.012 | 1.0172 | 1.0618 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7801.012 | 1.0275 | 1.0992 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7801.012 | 0.7658 | 0.2419 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7801.012 | 0.6531 | -0.0655 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7801.012 | 0.7408 | 0.1705 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7801.012 | 0.7054 | 0.0724 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7801.012 | 0.6706 | -0.0202 | 0.5600 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9186.049 | 1.1018 | 1.3006 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9186.049 | 1.0534 | 1.1560 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9186.049 | 1.0559 | 1.1636 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9186.049 | 0.9828 | 0.9505 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9186.049 | 0.7973 | 0.4419 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9186.049 | 0.7918 | 0.4277 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9186.049 | 0.6828 | 0.1525 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9186.049 | 0.7008 | 0.1967 | 0.6923 | |
| BT-483 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9186.049 | 0.7129 | 0.2268 | 0.6923 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7803.04 | 0.9970 | 0.9979 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7803.04 | 0.9908 | 0.9936 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7803.04 | 0.2054 | 0.1533 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7803.04 | 0.0639 | -0.2317 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7803.04 | 0.0815 | -0.1639 | 2.8752 |