Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7803.04 | 0.0804 | -0.1676 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7803.04 | 0.0785 | -0.1747 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7803.04 | 0.0855 | -0.1497 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7803.04 | 0.0937 | -0.1224 | 2.8752 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7804.04 | 1.0170 | 1.0134 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7804.04 | 1.0239 | 1.0187 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7804.04 | 0.5909 | 0.6259 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7804.04 | 0.0861 | -0.2382 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7804.04 | 0.0951 | -0.2080 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7804.04 | 0.1016 | -0.1871 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7804.04 | 0.0959 | -0.2054 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7804.04 | 0.1396 | -0.0788 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7804.04 | 0.1404 | -0.0767 | 2.5402 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10261.024 | 0.9788 | 0.9804 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10261.024 | 1.1635 | 1.1436 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10261.024 | 0.4749 | 0.4222 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10261.024 | 0.1219 | -0.2370 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 10261.024 | 0.1403 | -0.1862 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 10261.024 | 0.1339 | -0.2034 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 10261.024 | 0.1178 | -0.2489 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 10261.024 | 0.1612 | -0.1330 | 2.1838 | |
| BT-549 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 10261.024 | 0.1513 | -0.1576 | 2.1838 | |
| CAMA-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9210.024 | 1.0163 | 1.0375 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9210.024 | 1.0050 | 1.0114 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9210.024 | 1.0209 | 1.0481 | 0.8697 |