Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9347.012 | 1.0346 | 1.0470 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9347.012 | 1.0657 | 1.0887 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9347.012 | 1.0392 | 1.0532 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9347.012 | 0.7703 | 0.6737 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9347.012 | 0.3233 | -0.0745 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9347.012 | 0.3298 | -0.0618 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9347.012 | 0.3090 | -0.1027 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9347.012 | 0.3018 | -0.1171 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9347.012 | 0.2319 | -0.2624 | 1.4653 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7829.04 | 0.9759 | 0.9751 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7829.04 | 1.0094 | 1.0096 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7829.04 | 0.9795 | 0.9788 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7829.04 | 0.7406 | 0.7137 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7829.04 | 0.4323 | 0.2991 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7829.04 | 0.2368 | -0.0469 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7829.04 | 0.2603 | 0.0007 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7829.04 | 0.0870 | -0.4305 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7829.04 | 0.1140 | -0.3456 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9376.024 | 0.9536 | 0.9459 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9376.024 | 1.0582 | 1.0663 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9376.024 | 1.0178 | 1.0204 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9376.024 | 0.8145 | 0.7767 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9376.024 | 0.4316 | 0.2315 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9376.024 | 0.3007 | -0.0003 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9376.024 | 0.2291 | -0.1456 | 1.7329 |