Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9120.012 | 1.0113 | 1.0329 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9120.012 | 0.8809 | 0.6627 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9120.012 | 0.5780 | -0.0998 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9120.012 | 0.5473 | -0.1687 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9120.012 | 0.5394 | -0.1861 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9120.012 | 0.5324 | -0.2014 | 0.6867 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9120.012 | 0.4878 | -0.2968 | 0.6867 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7793.012 | 0.9725 | 0.9500 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7793.012 | 1.0309 | 1.0560 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7793.012 | 0.9874 | 0.9771 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7793.012 | 0.8464 | 0.7193 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7793.012 | 0.5286 | 0.1221 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7793.012 | 0.3699 | -0.1882 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7793.012 | 0.4471 | -0.0359 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7793.012 | 0.3489 | -0.2301 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7793.012 | 0.3522 | -0.2236 | 1.1030 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9146.049 | 0.8522 | 0.7306 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9146.049 | 0.8317 | 0.6929 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9146.049 | 0.9730 | 0.9511 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9146.049 | 0.6786 | 0.4083 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9146.049 | 0.5338 | 0.1334 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9146.049 | 0.4718 | 0.0136 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9146.049 | 0.5061 | 0.0800 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9146.049 | 0.4902 | 0.0494 | 1.1054 | |
| AU565 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9146.049 | 0.6311 | 0.3189 | 1.1054 |