Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9254.049 | 1.0768 | 1.1768 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9254.049 | 1.0684 | 1.1574 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9254.049 | 1.0800 | 1.1842 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9254.049 | 1.0067 | 1.0153 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9254.049 | 0.9948 | 0.9881 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 9254.049 | 0.9065 | 0.7872 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 9254.049 | 1.1866 | 1.4330 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 9254.049 | 0.7848 | 0.5152 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 9254.049 | 0.4135 | -0.2727 | 0.8730 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9258.024 | 1.1183 | 1.4746 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.000427 | uM | 9258.024 | 1.0327 | 1.1265 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.00213 | uM | 9258.024 | 1.0627 | 1.2457 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0107 | uM | 9258.024 | 0.8968 | 0.6254 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0533 | uM | 9258.024 | 1.0466 | 1.1811 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.267 | uM | 9258.024 | 1.1296 | 1.5225 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 1.33 | uM | 9258.024 | 1.0656 | 1.2573 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 6.67 | uM | 9258.024 | 0.7852 | 0.2618 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 33.3 | uM | 9258.024 | 0.0914 | -0.9790 | 0.5251 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7818.016 | 0.9543 | 0.9002 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.000427 | uM | 7818.016 | 1.0067 | 1.0147 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.00213 | uM | 7818.016 | 0.9071 | 0.7977 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0107 | uM | 7818.016 | 1.0064 | 1.0140 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.0533 | uM | 7818.016 | 0.9370 | 0.8625 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 0.267 | uM | 7818.016 | 0.9440 | 0.8779 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 1.33 | uM | 7818.016 | 0.8787 | 0.7362 | 0.9146 |