Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10754.149 | 0.9550 | 0.9331 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10754.149 | 0.9363 | 0.9050 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10754.149 | 1.0336 | 1.0494 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10754.149 | 0.9915 | 0.9874 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10754.149 | 0.9992 | 0.9987 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10754.149 | 0.9592 | 0.9394 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10754.149 | 0.8776 | 0.8161 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10754.149 | 0.6690 | 0.4861 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 11938.161 | 0.8883 | 0.7037 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 11938.161 | 0.8291 | 0.5519 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 11938.161 | 0.8975 | 0.7276 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 11938.161 | 0.8683 | 0.6520 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11938.161 | 0.8685 | 0.6526 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11938.161 | 0.9162 | 0.7765 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 11938.161 | 0.9933 | 0.9819 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 11938.161 | 0.9126 | 0.7671 | 0.7388 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 11938.161 | 0.7695 | 0.4028 | 0.7388 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 11660.149 | 0.9086 | 0.8284 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 11660.149 | 0.9037 | 0.8192 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 11660.149 | 0.9242 | 0.8578 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 11660.149 | 0.9470 | 0.9006 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 11660.149 | 0.9593 | 0.9237 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 11660.149 | 0.9111 | 0.8332 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 11660.149 | 0.9014 | 0.8149 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 11660.149 | 0.9019 | 0.8158 | 1.0690 |