Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 11660.149 | 0.8883 | 0.7903 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12003.166 | 0.8490 | 0.7182 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12003.166 | 0.8259 | 0.6748 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12003.166 | 0.9547 | 0.9159 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12003.166 | 0.8278 | 0.6784 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12003.166 | 0.8634 | 0.7452 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12003.166 | 0.8603 | 0.7394 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 12003.166 | 0.7807 | 0.5898 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 12003.166 | 0.5742 | 0.1955 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 12003.166 | 0.4496 | -0.0471 | 1.0782 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 11939.161 | 0.8819 | 0.8534 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 11939.161 | 0.9296 | 0.9135 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 11939.161 | 0.9615 | 0.9531 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 11939.161 | 0.9467 | 0.9348 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11939.161 | 0.9683 | 0.9614 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11939.161 | 0.9094 | 0.8882 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 11939.161 | 1.0000 | 1.0000 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 11939.161 | 0.8476 | 0.8094 | 1.6513 | |
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 11939.161 | 0.6399 | 0.5263 | 1.6513 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.000171 | uM | 12509.167 | 0.9448 | 0.9220 | 1.4256 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.000853 | uM | 12509.167 | 1.0398 | 1.0555 | 1.4256 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.00427 | uM | 12509.167 | 1.0000 | 0.9999 | 1.4256 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.0213 | uM | 12509.167 | 1.0429 | 1.0598 | 1.4256 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.107 | uM | 12509.167 | 1.0022 | 1.0031 | 1.4256 | |
| 184A1 | NM | Basal | FTase Inhibitor I | Ftase | MAPK | 0.533 | uM | 12509.167 | 0.9508 | 0.9305 | 1.4256 |